Original Research Article I Volume 6 I Issue 1 I 2018

Prognostic Value of Adrenomedullin in Patients with Left Ventricular Systolic Dysfunction After an Acute Myocardial Infarction

Ahmed Yassin, Mohamed Abo Hamela, Ahmed Battah, Amal Rizk, Sherif Mokhtar

Biolife; 2018, 6(1), pp 1-8

DOI: https://doi.org/10.5281/zenodo.7397310

Abstract:

This study sought to assess the prognostic impact of adrenomedullin ADM after an acute myocardial infarction (AMI). Adrenomedullin (ADM) is elevated in heart failure (HF) and after AMI and compared it with N-terminal pro-B-type natriuretic peptide (NTproBNP), a marker of death and HF. We measured plasma ADM and NTproBNP in 60 consecutive post-ST elevated AMI patients with systolic dysfunction (< EF 50%), (45 men, represents 75% with mean age57.6±8.4 years old), 3 to 5 days after chest pain onset

Keywords:

ADM (adrenomedullin), AMI (acute myocardial infarction), AUC (area under the curve, MACE (major adverse cardiovascular events).

References:

  1. De Lemos JA. Benchmarks for the assessment of novel cardiovascular biomarkers. Circulation 2007;115: 949-52.
  2. Chidsey CA, Braunwald E, Morrow AG. Catecholamine excretion and cardiac stores of norepinephrine in congestive heart failure. Am J Med 1965;39:442-51.
  3. Daniels LB, Maisel AS. Natriuretic peptides. J Am Coll Cardiol 2007;50:2357-68.
  4. Fujisawa, Y., Nagai Y., Miyatake A et al., 2004. Renal effects of new member of adrenomedullin family, adrenomedullin2 in rats. Eur. J. Pharmacol., 497(1): 75-80.
  5. Garrone, P.; Biondi-Zoccai, G. & Salvetti, I. (2009). Quantitative coronary angiography in the current era: principles and applications. J Interv Cardiol 22:527-536.
  6. Jougasaki M, Wei CM, McKinley LJ,Burnett JC Jr. Elevation of circulating and ventricular adrenomedullin in human congestive
  7. heart failure. Circulation 1995;92:286-9
  8. Klip IT1Voors AAAnker SDHillege HLStruck J,OPTIMAAL investigatorsHeart. 2011 Jun;97(11):892-8. doi: 10.1136/hrt.2010.210948. Epub 2011 Mar 17.
  9. Tania Luthra, Rahul Agarwal, Mamidala Estari, Uma Adepally, Subhabrata Sen. A novel
    library of -arylketones as potential inhibitors of α-glucosidase: Their design, synthesis, in
    vitro and in vivo studies. Nature-Scientific Reports, 2017, 7(1), 1-13. DOI: 10.1038/s41598-
    017-13798-y
  10. Nagaya N, Satoh T, Nishikimi T, et al. Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure. Circulation 2000;101:498-503.
  11. Phillip Haaf  Raphael twerenbold ,Tobias Reichlin ,Jonathan Faoro ,Miriam Reiter,ChristopheMeune, Department of Internal Medicine, Division of Cardiology, University Hospital, Basel, Switzerland. International journal of cardiology (Impact Factor: 6.18). 11/2012; 168(2). DOI: 10.1016/j.ijcard.2012.10.025
  12. Tang WH, Francis GS, Morrow DA, et al. National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: clinical utilization of cardiac biomarkers...

Article Dates:

Received: 25 November 2017; Accepted: 30 December 2017; Published: 11 January 2018

How To Cite:

Ahmed Yassin, Mohamed Abo Hamela, Ahmed Battah, Amal Rizk, & Sherif Mokhtar. (2022). Prognostic Value of Adrenomedullin in Patients with Left Ventricular Systolic Dysfunction After an Acute Myocardial Infarction. Biolife, 6(1), 1–8. https://doi.org/10.5281/zenodo.7397310

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