Original Research Article I Volume 5 I Issue 4 I 2017

Clinical Evaluation of plasma Gelsolin as a novel marker for sepsis: comparison with Procalcitonin regarding early diagnosis and prognosis in septic patients

Hazem El-Akabawy; Emad Omer; Hossam Mowafy; Iris Nessim; Ahmed Maghraby

Biolife, Volume 5, Issue 4, 2017, pp 416–427

DOI:https://doi.org/10.5281/zenodo.7371656

Abstract:

Gelsolin is an actin-binding plasma protein that is part of an actin-scavenging system. Gelsolin serves a protective role against tissue injuries and may play a crucial role in the pathophysiology of sepsis. The present study was designed to evaluate the diagnostic utility and the prognostic value of pGSN in the critically ill septic patients.

Keywords:

Gelsolin; Procalcitonin; Sepsis; APACHE II, SOFA score

References:

  1. Becker K, Snider R, Nylen E. (2008). Procalcitonin assay in systemic inflammation, infection and sepsis: clinical utility and limitations. Crit Care Med. 36 (3):941–952.
  2. Janmey P, Lind S. (1987). Capacity of human serum to depolymerize actin filaments. Blood. 70:524-530.
  3. Kwiatkowski D, Mehl R, Izumo S, et al. (1988). Muscle is the major source of plasma gelsolin. J Biol Chern. 263:8239-8243.
  4. Lind S, Smith D, Janmey P, Stossel T. (1986). Role of plasma gelsolin and the vitamin D-binding protein in clearing actin from the circulation. J Clin Invest. 78:736-742.
  5. Goldschmidt-Clermont P, Van Baelen H, Bouillon R, et al. (1988). Role of group specific component (vitamin D binding protein) in clearance of actin from the circulation in the rabbit. J Clin Invest. 81:1519-1527.
  6. Lee W, Galbraith R. (1992). The extracellular actin-scavenger system and actin toxicity. N Engl J Med. 326:1335-1341.
  7. Lee W, Reines D, Watt G, et al. (1989). Alterations in Gc protein levels and complexing in septic shock. Circ Shock. 28:249-255.
  8. Smith D, Janmey P, Lind S. (1988). Circulating actin-gelsolin complexes following oleic acid-induced lung injury. Am J Pathol. 130: 261-267.
  9. Smith D, Janmey P, Herbert T, Lind S. (1987). Quantitative measurement of plasma gelsolin and its incorporation into fibrin clots. J Lab Clin Med. 110:189-195.
  10. Dahl B, Schiodt F, Ott P, et al. (1999). Plasma gelsolin is reduced in trauma patients. Shock. 12:102–104.
  11. Lee P, Drager L, Stossel T, et al. (2006). Relationship of plasma gelsolin levels to outcomes in critically ill surgical patients. Ann Surg. 243:399–403.....

Article Dates:

Received: 2 October 2017; Accepted; 20 November 2017; Available online : 3 December 2017

How To Cite:

Hazem El-Akabawy, Emad Omer, Hossam Mowafy, Iris Nessim, & Ahmed Maghraby. (2022). Clinical Evaluation of plasma Gelsolin as a novel marker for sepsis: comparison with Procalcitonin regarding early diagnosis and prognosis in septic patients. Biolife, 5(4), 416–427. https://doi.org/10.5281/zenodo.7371656

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